Peptoids & their use in drug discovery

Peptoids are small sequences of the amino acid glycine modified on the nitrogen atom. They look like amino acids but the ramification is located on the nitrogen rather than the alpha-carbon. Plus, as the amino acid glycine, they also lack chirality. The concept of peptoids was first introduced in the 80s. [1] Back at the time, important biological targets such as enzymes, growth factors and antibodies were quickly identified, produced and validated due to new discoveries of gene editing. However, small organic molecules to screen against those biological targets weren’t made at the same pace.

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